Infection and Poliomyelitis

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Poliomyelitis as a Complex Infection

Young cynomolgus monkeys inoculated intracerebrally with an attenuated Type 1 polio virus and, after 5 days, with a monkey adapted Coxsackie A-14 virus frequently became paralyzed. Neither virus alone was capable of inducing paralysis. Similar results were observed when the AB IV strain of Coxsackie A-7 was substituted for the A-14 virus. In this case the 2nd inoculation was made intramuscularl...

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Intraspinous Infection in Experimental Poliomyelitis

By intraspinous injections of specimens of poliomyelitic virus of suitable virulence infection can be caused regularly in Macacus rhesus monkeys. The virus passes from the subarachnoid spaces into the nervous tissues in which it multiplies, and into the blood. The constant involvement of the pia-arachnoid membranes in poliomyelitis, even when no paralysis occurs, and the fact that infection can...

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The Natural History of Experimental Poliomyelitis Infection

1. Eight rhesus monkeys with experimental poliomyelitis following intrasciatic inoculation of "M.V." virus were used to study the extent of virus spread in the central and peripheral nervous systems and the question of its elimination in the nasal secretions. 2. Tests on nasal secretions collected on absorbent cotton plugs daily and continuously from the moment of inoculation to the end of the ...

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ژورنال

عنوان ژورنال: BMJ

سال: 1954

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.4853.99